DCIS grade and the presence of comedonecrosis were abstracted from selleck chemicals llc
women's medical records. Multivariate linear regression was used to test whether education or financial status was associated with participants' anxiety and depression at baseline and at the 9-month follow-up, and whether education or financial status predicted change in participants' anxiety or depression after controlling for baseline levels. A chi-square test was used to assess whether the probability of scoring ��16 on the CES-D and ��26 on the IES at baseline and at the 9-month follow-up differed by education and financial status. The procedure recommended by Baron and Kenny35 was used to test whether level of social support explained (ie, mediated) the relationship between SES and change in the dependent variables (anxiety and depression) after SAR245409
controlling for baseline levels. First, the hypothesized mediator, social support, was regressed on the independent variable, SES, to assess whether a relation existed between them. Second, the dependent variables were regressed separately on SES to test whether they were related. Third, the dependent variables were regressed on social support. Fourth, the dependent variables were regressed on social support and SES simultaneously. Mediation was supported if the first 3 models were statistically significant and the effect of group on change in the dependent variables was lessened or eliminated in the presence of social support.35 To test whether social support buffered (ie, moderated) the association between SES and change in anxiety and depression, a SES by social support interaction term was entered into a multivariate linear regression model to predict change in anxiety and depression. All multivariate models controlled for sociodemographic (age, marital status, employment status, and race/ethnicity) and clinical (menopausal status, receipt of tamoxifen, number of comorbidities, receipt of mastectomy, grade, and presence of comedonecrosis) factors that were hypothesized a priori as being potential heptaminol
confounders of the association between SES and anxiety and depression or that were associated with both SES and distress in univariate analyses. All statistical tests were 2-sided, and all analyses were conducted using the SAS system for Windows (Release 9.1; SAS Institute, Cary, NC). Eight hundred fifteen women with newly diagnosed DCIS were identified from the Rapid Case Registry. Of these, 45 women were deemed ineligible, 205 declined to participate when contacted, and 72 women did not respond despite repeated attempts to contact them. Four hundred eighty-seven women (64% of eligible patients) consented to participate and completed the baseline questionnaires. These women were younger than the women who did not enroll in the study (P < .