Chi-square, Fisher��s exact tests, student��s t-test, and Mann�CWhitney U test, whatever appropriate, were used to test the significance between the variables, and multiple logistic regression was used to identify factors associated with in-hospital mortality. Altogether, 386 patients with AIS were studied, of which 113 (29.3%) had a documented previous statin use. A total of 62 (16.1%) patients with AIS died in hospital. In-hospital mortality was significantly lower among previous statin users (P?=?0.013). The presence of atrial fibrillation (AF) increased in-hospital www.selleckchem.com
mortality among patients with or without previous statin use. The independent predictors for in-hospital mortality among AIS patients without previous statin use were the presence of diabetes mellitus (P?=?0.047), AF (P?=?0.045), and renal impairment (P?<?0.001). The prophylactic administration of statins significantly reduces post-AIS in-hospital mortality. Furthermore, the identification of predictors of in-hospital mortality might reduce death rates and enhance the application of specific therapeutic and management strategies to patients at a high risk of dying. ""Huntington's disease (HD) is a rare multifactorial neurodegenerative disease. Both its natural course and any placebo <a href="http://en.wikipedia.org/wiki/Megestrol_acetate
">Megestrol Acetate effect are poorly known. All are obstacles to design randomized controlled trials (RCTs). We conducted meta-analyses of RCTs and cohorts on all parameters of the Unified Huntington's Disease Rating Scale to determine the most appropriate outcomes and to minimize the number of patients required to design RCTs in HD. Twenty-four RCTs were included, involving 838 patients with a mean age of 50.0?��?2.3?years and a mean total functional capacity (TFC) score of 9.8?��?0.6. Nineteen cohorts were included involving 1939 patients with a mean age of 48.9?��?2.3?years and a mean TFC of 10.1?��?0.7. Significant deterioration was observed in RCTs for all scores except behavioral score. Effect sizes were comparable between RCTs and cohorts for each test except that there was a significant difference for TFC. The weighted mean deterioration per year on the TFC scale was ?0.5 (0.2) in RCTs and ?0.8 (0.2) in cohorts. The lowest number of patients required per group in a RCT was for GSK2118436
TFC (19 per group), whereas 30 patients would be required per group for the total motor score (TMS). For cognition, the verbal fluency test required the smallest number of patients: 104 per group. In conclusion, TMS and TFC are the most appropriate outcomes to design RCTs on HD likewise the verbal fluency test for cognition. Our results suggest an effect of placebo administration on the total functional capacity. ""Doctor-shopping is a patient behaviour characterized by simultaneous consultations of several physicians during the same period.