Receiver��operating characteristics (ROC) curves and calibration plots were constructed to describe performance of the previous model for predicting ongoing viability in this population. First trimester pregnancy outcome was known for 172 women (89%). 97/172 (56.3%) pregnancies were viable and 75/172 (43.6%) were non-viable at the end of the first trimester. The model predicted viability with an area under the ROC Curve (AUC) of 0.8334 (95% CI, 0.7669�C0.9000) which was better than in the original internal validation set (AUC 0.774 (95% CI, 0.701�C0.848). The scoring system also performed considerably better with AUC of 0.8259 (95% CI, 0.7561�C0.8958) in this study compared with AUC of 0.771 (95% CI, 0.698�C0.844) in the original validation set. Calibration plots for both the model and scoring system show good calibration. Both the model and the scoring system performed considerably better in an external click here
validation confirming that these are potentially practical tools and of similar performance, in the prediction of viability in IPUV. ""To evaluate the response in lung growth (lung-to-head ratio) after fetal endoscopic tracheal occlusion (FETO) for severe congenital diaphragmatic hernia (CDH) in the prediction of neonatal survival. Between January 2006 and December 2009, http://www.selleckchem.com/
the lung-to-head ratio was evaluated before and every two weeks after FETO in cases of severe isolated CDH (LHR < 1.0 with liver up). A total of 35 fetuses undergoing FETO were evaluated. The overall survival rate survival was 19/35 (54.3%) cases after FETO. The LHR increased progressively up to 4 weeks after fetal intervention (P < 0.01). Six weeks after FETO, a small decrease in the LHR was observed. The increase of LHR was significantly higher in cases that survived in comparison to those that died 2, 4 and 6 weeks after FETO (P < 0.01). Using ROC analysis, it was possible to determine that LHR ? 0.71 before FETO was associated with neonatal mortality (RR: 4.08; 95% CI: 1.3�C12.0). The LHR before and after FETO can be used to predict neonatal survival. ""To evaluate the correlation between sonographic measurements of nuchal translucency (NT) as detailed at birth to neonatal birth weight and LGA in non-diabetic population. A retrospective analysis was performed on all singleton term pregnancies delivered at our hospital between 2004 and 2008. Data collected at admission to birth included maternal Birinapant
age, parity, NT measurement, and results of glucose challenge test. Data collected after birth included birth weight, gestational age at delivery, and fetal gender. The study population was comprised of 1649 patients. The mean NT was 1.3 �� 0.5 mm. Male fetuses had a significantly thicker NT (1.3 �� 0.5 vs. 1.2 �� 0.4; P < 0.001). NT significantly correlated to birth weight (P = 0.002). This correlation was independent of the neonatal gender. The median NT in the large for gestational age (LGA) neonates was significantly higher than in the non-LGA neonates (1.4 mm vs. 1.2 mm, P = 0.