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Nintedanib: An Quintessential Enjoyment!

Parainfluenza viruses were not investigated by PCR during the time of the study, but only diagnosed by IF and virus isolation. The different coronaviruses, HKU-1, NL63, 229E and OC43, were diagnosed by separate PCR assays, but in the present study they were considered to be a single group due to the small numbers of cases. The most common coronavirus was HCoV-OC43 (seven patients), followed by HCoV-NL63 (six patients). HCoV-HKU1 was only found in one patient and there were no findings of HCoV-229E. The picornavirus PCR assay was optimised for rhinoviruses, but could also detect most enterovirus species. Data on comorbidity including atopic characteristics, duration of hospitalisation, diagnosis at discharge, C-reactive protein (CRP), oxygen treatment, chest x-ray results, and admission to the paediatric intensive care unit (PICU) were collected from the patient records. The investigator was blinded to whether the patients had single or multiple viral findings when reviewing the records. The study was approved by the Stockholm Regional Research Ethics Committee. Age was counted in whole months. Categorical Carfilzomib data were examined using the ��2 test. Wilcoxon and Mann�CWhitney tests were used to compare continuous data in two groups, and were performed with the SPSS and Statistica software. The mean ages of patients with multiple and single coronavirus findings were 14.6?months and 7.2?months, respectively, and for picornavirus findings, 11.8?months and 9.8?months, respectively. The mean age of all the children with mixed infections, including RSV, was 12.7?months, compared to 5.7?months for single infections (p?<?0.01). Males dominated the series and accounted for 60% of patients with single findings and 62% of those with multiple findings. Data from patient records were obtained from 129 episodes in 127 patients (Table?2). There was no difference in clinical data such as CRP, oxygen treatment, duration of hospitalisation and admission to PICU between patients with single and double infections. A chest x-ray was performed in 60% of the children. There was a greater tendency to perform a chest x-ray if the patient had multiple detectable viruses than if there was a single finding, (67% versus 58%,), but the difference was not statistically significant (p?=?0.33). The main diagnoses at discharge were croup, lower respiratory infection (LRI), upper respiratory infection (URI) and wheezing. Wheezing was the most common diagnosis in all groups (36�C88%) except among children only infected with the coronavirus. No differences regarding diagnoses were found between children with multiple findings and those with a single finding.</div>
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