Following biopsy and exclusion of invasive disease, therapy involves conventional excision, MMS, topical treatment or radiotherapy. Lentigo maligna presents several challenges in diagnosis and management, including its propensity to involve hair follicle adnexae. This may create histological difficulty in distinguishing such Quisinostat
foci from invasive melanoma. In this case, a nodule of atypical melanocytes appeared to lie within the dermis, potentially altering treatment and prognosis. The use of laminin-5 provided a means of resolving this diagnostic dilemma, facilitating continuation of MMS to tumour clearance. Laminin-5 staining to facilitate the treatment of lentigo maligna by MMS has not previously been reported and we wish to highlight this fascinating example. IMC-P36 Utilization and costs of healthcare resources in patients with metastatic melanoma PD0325901 in vivo
in the US S. Wang, Z. Zhao, B. Barber, S. Gao, V. Wagner Amgen, Inc., Thousand Oaks, CA, USA The incidence of metastatic melanoma (MM) has increased during the last three decades and the death rate has risen faster than most other cancers. MM carries severe burdens to patients, their families, and the payers. However, little information exists regarding the economic burden of MM. Using a large US medical claims database, this study assessed healthcare resource utilization and costs among patients with MM in the real-world practice setting. Patients were identified between 2005 and 2010 using ��2 melanoma diagnoses (ICD-9-CM: 172.xx, V10.82) and ��2 diagnoses for metastasis (ICD-9-CM: 197.xx, 198.xx). The index date was the first date of metastasis diagnosis. Patients who had other primary malignant tumors prior to the melanoma diagnosis, were younger than 18?years old at the index, or had a pre-index period of <6?months, were excluded from the analysis. Patients were followed from the index date to death, disenrollment, or end of the study period (6/30/2010), whichever occurred first. Healthcare utilization and costs (adjusted to 2010 dollars) were examined per patient-year for office visits, outpatient visits, outpatient <a href="http://www.selleckchem.com/products/epz-6438.html
">EPZ-6438 solubility dmso pharmacy, emergency room (ER) visits and inpatient hospitalization. A total of 2546 patients with metastatic melanoma were identified. Mean (�� standard deviation) age at the index date was 60.6 (�� 14.0) years and 36.5% were female. Overall, 87.3% of the patients had physician office visits with a mean of 24.0 visits per person-year, 64.7% had ER visits with a mean of 12.9 visits per person-year, 90.6% had outpatient visits with a mean of 8.3 visits per person-year, and 82.2% were hospitalized with a mean of 12.4 hospitalizations per person-year. The mean total costs per patient-year were $127?204, which was driven mainly by inpatient costs ($60?355/patient-year) and outpatient costs ($34?540/patient-year). Inpatient and outpatient care are key cost drivers in the medical management of patients with advanced melanoma.