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Data were obtained from both electronic medical records and hospital charts. Covariates included recipient demographics, pretransplant information, intraoperative data, detailed donor demographics, and postoperative outcomes. Both calculated and exception Model for End-Stage Liver Disease (MELD) scores were included in the recipient analysis. Indications for both primary LT and re-LT were evaluated. In accordance with the model published by Feng et al.,[20] the donor risk index was calculated for each donor/recipient pair. Each reported BC was reviewed in detail for the type of complication (leak, stricture, or both), its location, and the type and timing of the intervention. In all BC cases, hepatic artery patency was evaluated either radiologically (duplex ultrasound, magnetic www.selleckchem.com resonance imaging, computed tomography angiography, or conventional angiography) or during surgical exploration. The reconstruction technique (duct-to-duct or Roux-en-Y) was also coded for primary LT and re-LT. The statistical analysis was performed with SPSS Statistics 20 (IBM Corp., 2010). Continuous variables GDC-941 were compared between groups with the t test or the rank-sum test as appropriate. Categorical variables were compared between groups with the chi-square test or Fisher's exact test as appropriate. Patient survival was compared between groups with and without BCs with Kaplan-Meier survival curves via the log-rank method. Multivariate Cox regression analysis was used to identify predictors of death and graft failure after re-LT. BCs were treated as a time-varying covariate to account for variations in the time of presentation of these complications. Only variables with a P value?<?0.05 in the univariate analysis were entered into the Cox regression model. The follow-up duration was calculated from the date of retransplantation to the date of death, the date of the last documented follow-up at the completion of data collection (February 2012), or the date of subsequent retransplantation (if required). Two-sided tests of hypotheses were conducted, and a P value?<?0.05 was the criterion for statistical significance. This study was approved by the institutional <a href="http://www.selleckchem.com/products/PD-0325901.html">PD0325901 review board at the Hospital of the University of Pennsylvania. During the study period, adult LT was performed 1344 times; 110 of these procedures (8.2%) were re-LT performed for 104 recipients. Six third transplants were included, with each re-LT representing a distinct event for analysis. The minimum follow-up was 10 months, and the average follow-up was 55 months. The recipient demographics are presented in Table 1. The median age at retransplantation was 49 years (range?=?19-69 years). The majority of the recipients were male and Caucasian. The average listed MELD score at retransplantation was 30.5. The median number of days from relisting to retransplantation was 737.
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