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14 Considering a predictor number of 10, at least 150 patients with DM were required to detect the potential predictors of OAB and its component symptoms. Thus, the present study of 279 diabetes patients met the aforementioned criteria. Table?1 summarizes the demographic and clinical characteristics of the 279 patients with DM and the 558 control subjects. The mean age of the 837 participants http://www.selleckchem.com/products/CP-673451.html was 63.2?��?10.6?years (range 40�C90?years). Diabetic patients had higher mean BMI and higher proportions of chronic illnesses, such as hypertension, heart disease, hyperlipidemia and stroke, than the non-DM group. Of the 279 DM patients, 21.1% and 31.9% reported a DM duration of 20 or more years and 10 to <20?years, respectively. Diabetes was mainly controlled by oral hypoglycemia agents (64.5%). More than one-quarter of diabetic patients (28.3%, n?=?79) had HbA1c levels of 9.0% or more, whereas nearly half of the diabetic patients (48.4%, n?=?135) had HbA1c levels of 7.0�C8.9%. Table?2 shows OABSS, OAB, and its component symptoms for patients <a href="https://en.wikipedia.org/wiki/Crotamiton">crotamiton with DM and the control group. When compared with the control group, diabetic patients had higher OABSS (t?=??2.467, P?=?0.014), higher occurrence of OAB/urgency (OR 2.03, 95% CI 1.44�C2.86) and nocturia (OR 1.44, 95% CI 1.08�C1.93). There was no significantly proportional difference in UUI (OR?=?1.32, 95% CI 0.86�C2.04) and daytime frequency (OR 0.77, 95% CI 0.56�C1.05) between the diabetic and control groups. Just 26.9% (21/78) of patients with DM and OAB had ever discussed their urinary symptoms with their physicians in the prior year compared with 42.9% (39/91) of subjects with OAB in the control group. Table?3 shows the multiple logistic regression analyses for exploring the potential predictors of OAB and its component symptoms in patients with type?2 diabetes. After controlling for all other variables, a high HbA1c level and age were independent predictors of OAB/urgency, UUI and nocturia. No independent predictor was found for daytime selleck compound frequency. In the present study, participants with type?2 DM had significantly higher OABSS, and increased OR for OAB/urgency and nocturia. In multivariate logistical regression, higher HbA1c level was significantly associated with OAB/urgency, UUI and nocturia, suggesting that the effects of diabetes as a result of poor blood-sugar control could play a crucial role in the development of OAB symptoms. Our understanding of the association of urological symptoms as bladder complications of DM has greatly advanced in the past decade.
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