• The decision between the two was made by the attending physician at each hospital and was based upon the surgeon's best judgement, knowledge and expertise. The trauma mechanism was classified as a simple fall, meaning a fall from persons height, high-energetic (e.g., a traffic-related accident) or ��other��. Data were analysed using the Statistical Package Glafenine for the Social Sciences (SPSS) version 16.0 for Windows. Outcomes after operative and non-operative treatments were compared. Results of categorical variables (gender, AO-types and sub-types, delayed union, radial nerve palsy, injuries and trauma mechanism) were analysed using the Chi-squared test. Results of numerical variables (age and consolidation time) were analysed using the Mann�CWhitney U-test. All tests were two sided. P-values <0.05 were considered statistically significant. In total, 186 patients were included in this study. Table 1 shows the demographic data of this cohort for the patients in this study. As many as 91 patients had been treated non-operatively. The majority was female (60.4%) and the <a href="http://www.selleckchem.com/products/E7080.html">http://www.selleckchem.com/products/E7080.html mean age was 58.7?��?1.5?years. The operatively treated group consists of 95 patients, 53.7% was female, with a median age of 61.1?years. No statistically significant difference could be found with respect to this data between the groups. In the non-operatively treated group the left humerus was affected in 51.6% of patients, which was not statistically different from the operative group (62.2%). In 83.3% of the patients, the humeral shaft injury was a solitary injury, and in 72% of patients the fracture resulted after a simple fall. No statistical difference was found between both groups. In the operative group 82.1% of the patients were treated using intramedullary nailing, 11.6% using plate osteosynthesis, 5.3% using external fixation and in one (1.1%) patient only cerclage wires were used. Fig. 1 shows a detailed overview of fractures by AO subgroups. This shows that type A humeral shaft fractures were found most frequently (50.0% of the patients) and type C was the least common (8.1% of the patients). In the non-operatively treated Selleckchem MAPK inhibitor group, the A1 spiral fracture was the most common subtype (28.6%) and in the operatively treated group the A3 transverse fracture (26.3%). Table 2 shows the time it took to achieve radiological consolidation in weeks from the day of the fracture per AO type and sub-type. In the non-operatively treated group, the time to achieve radiological consolidation ranged from a median of 11?weeks in the AO type A2 subgroup to 15?weeks in the B2 and A3 subgroups. In the operative group, time to consolidation ranged from a median of 12?weeks (A2 sub-type) to 28?weeks (B3 sub-type), which did not differ statistically from the non-operative group. Overall, 17 of the patients (9.1%) developed radial nerve palsy (Table 3). No statistically significant difference was found between the two groups.

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