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  • 001). High umbilical cord serum levels of CCL17 were associated with infantile AD development even in 62 neonates born to mothers without AD (median 1514.4 vs. 740.6?pg/mL, P<0.001) and 38 neonates born to mothers with no allergies (median 1624.2 vs. 740.6?pg/mL, P<0.001). The summary estimates for umbilical cord serum CCL17 in the diagnosis of infantile AD were: sensitivity 85.7% (95% confidence interval: 72.8�C98.7), specificity 73.8% (60.5�C87.1), positive predictive value 68.6% (53.2�C84.0) and negative predictive value 88.6% (78.0�C99.1). Conclusion and Clinical <a href="http://www.selleckchem.com/products/PD-0332991.html">Palbociclib Relevance These findings suggest that the umbilical cord blood CCL17 may be involved in the pathogenesis of infantile AD and in fetomaternal inheritance. Serum levels of CCL17 from umbilical cord Cilengitide blood may be a predictive marker for AD in infancy. ""To cite this article: Mat��as V, San Feliciano L, Fern��ndez JE, Lape?a S, Garrido E, Ardura J, Soga MJ, Arag��n MP, Remesal A, Benito F, Andr��s J, Centeno F, Marug��n V, Bachiller R, Bermejo-Martin JF. Host and environmental factors influencing respiratory secretion of pro-wheezing biomarkers in preterm children. Pediatric Allergy Immunology 2012: 23: 441�C447. Cytokines are actively secreted by the respiratory mucosa of preterm children and participate in the pathogenesis of wheezing. This study aimed to identify the factors that could potentially influence respiratory secretion of cytokines in these children. A nasopharyngeal aspirate (NPA) was collected from 77 preterm children 1?yr after birth. NPAs from selleck chemicals llc 14 healthy, 1-yr-old term children were collected in parallel. 27 cytokines were measured in the NPAs using a multiplex assay. Multivariate stepwise regression analysis with Bonferroni correction evidenced that the variable [daycare attendance] was associated with higher levels of [monocyte chemoattractant protein-1 (MCP-1), IL-6, vascular endothelial growth factor (VEGF), IL-1��, IL-10, tumor necrosis factor (TNF)-��]; [male sex] with higher levels of (MCP-1, VEGF, and IL-1��); [smokers at home] was associated with higher levels of MCP-1 (p?<?0.0013). In turn, [prophylaxis with palivizumab] was associated with lower levels of (IL-6, IL-7) (p?<?0.0013). All these mediators participate in the pathogenesis of asthma and recurrent wheezing. Preterm children secreted higher levels of chemokines (interferon-gamma inducible protein-10, macrophage inflammatory protein-1��, Eotaxin, MCP-1), growth factors (platelet-derived growth factor-bb, VEGF, fibroblast growth factor-basic, granulocyte macrophage colony-stimulating factor), Th1 (IL12, interferon-��), Th2 (IL-9, IL-13), Th17 (IL-6, IL-17) cytokines, and immunomodulatory mediators (IL1RA and granulocyte colony-stimulating factor) than term children. In conclusion, we have identified for the first time a group of individual and environmental factors influencing respiratory secretion of cytokines in preterm children at the long term after birth.</div>

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