5% cholesterol-rich diet for eight weeks. Blood volume flow, blood mean velocity, wall mean thickness and Bcl-2 inhibitor
percentage of luminal cross-sectional area of stenosis in the all of the rabbits' arteries were measured by color Doppler and B-mode ultrasonography weekly, after which the rabbits were sacrificed, and their vessels were processed for histopathology. Results:?Histopathology results showed progressive changes, from the lipid-laden cells and fibrous connective tissue proliferation, up to fibro-lipid plaque formation, resulting in vessel wall thickening, remodeling, neovascularization and lumen narrowing. The color Doppler and B-mode ultrasonography measurements showed a significant reduction in the luminal cross-sectional area at the stenotic region within eight weeks (P?<?0.05). Conclusion:?We successfully developed a new rabbit carotid artery model of atherosclerotic plaque neovascularization, which is not only quickly and easily reproducible and inexpensive but also without mortality. The merits of our model render the <a href="http://www.selleckchem.com/products/MDV3100.html
">Enzalutamide cost evaluation of carotid artery stenosis and its treatment strategies more feasible in humans. P Methil1, C Ramakrishnan1, M Mazarudheen1 1Neurology & Stroke, KG Hospital & Postgraduate Institute, Coimbatore, India Introduction:?Magnetic resonance angiography (MRA) and Transcranial Doppler (TCD) are both screening tests for intracranial stenosis. SB 431542
MRA findings and TCD findings were compared in patients with Transient ischemic attack (TIA), stroke or suspected cerebro vascular disease. Materials and methods:?280 patients were studied over a 3 year period between 2009 & 2012. There were 192 male & 88 female patients with in the age group 32 to 78 years.A complete TCD examination & MRA was performed in all the patients. Results:?In the 280 patients studied, there was significant agreement between TCD & MRA.The results were discordant in only 7% of cases.In the discordant cases MRA showed greater stenosis & TCD showed insignificant stenosis. Conclusion:?In our study we found a 93% concordance between MRA & TCD for evaluation of intracranial stenosis.In cases where there is no concordance, MRA showed higher degree of stenosis in 90% of the cases. Y Moodley1, B Biccard1 1University of Kwazulu-Natal, Department of Anaesthetics, Durban, South Africa Introduction:?Current surgical management for carotid artery disease includes carotid endarterectomy (CEA). In-hospital stroke and death following CEA might be associated with preinduction blood pressure measurements and other clinical risk factors. Aims:?The aim of this study was to determine whether there is an association between preinduction blood pressure, other clinical risk factors, and in-hospital stroke or death following CEA in a cohort of South African patients.