5 (95% CI 2.2�C15.8) (P?<?0.001) for impaired development in at least one domain in children of ED mothers. As presented in Table?4, children of mothers with AN had significantly higher raw scores of several subdomains such as fine motor skills, memory, expressive language skills and social skills than controls (P-values adjusted for multiple comparisons). Similarly, children of mothers with BN had significantly higher raw scores of expressive language skills. <a href="http://www.selleck.cn/products/otx015.html
">OTX015 There were no significant differences in raw scores between the subgroups of AN and BN. In the children of mothers with ED, head circumference at birth correlated significantly with language skills (r?=?0.32, P?<?0.05). In the subgroup of BN, head circumference at birth correlated with planning/organising (r?=?0.64, P?<?0.01), social skills (r?=?0.51, P?<?0.05) and language skills (r?=?0.48, P?<?0.05). Similar correlations were not found in the AN group (r?=?0.05, r?=?0.20 and r?=?0.18, respectively) or the control group (r?=?0.10, r?=?0.09 and r?=?0.04, respectively). The correlation coefficients for head circumference versus planning/organising, language skills and social skills were significantly different between the BN and the control group (P?<?0.01, P?<?0.05 <a href="http://www.selleckchem.com/products/BKM-120.html
">BKM120 research buy and P?<?0.05, respectively). Furthermore, the correlation coefficient for head circumference versus planning/organising was significantly different between the BN and the AN group (P?<?0.05). In the present study, we found that children born to mothers with ED had a lower birthweight but displayed an early catch-up in weight. In contrast, the average head circumference was found to be delayed up to at least 18?months of age. The finding of reduced head growth has to our knowledge not been reported previously and was found in both the AN and BN subgroups. The children of mothers, who worried much about not being a good mother (MAMA question number 1) 3?months after delivery, exhibited more pronounced delays in growth development including head growth. Furthermore, children of mothers with AN or BN had significantly higher FTF scores than controls reflecting difficulties in language and social skills. Our present results generally confirm <a href="http://www.selleckchem.com/products/pexidartinib-plx3397.html
">Pexidartinib previous findings of an early catch-up in weight/BMI in children born to mothers with ED.[7, 10] The novel finding of a delayed postnatal development of head circumference in children born to mothers with ED could be associated with delayed brain growth. This retarded head growth is probably not due to postnatal undernutrition, as body weight was normalised after only 3?months. Rather, the lower mean weight and head circumference at the time of birth might be caused by fetal undernutrition during pregnancy. In comparison to control infants, our children born to mothers with a previous history of AN exhibited a mean reduction of 300?g in birthweight and of 1.5?cm in head circumference at birth.