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The way STA-9090 Affected Our Everyday Lives 2011

4%) STA-9090 in vivo but a lower prevalence of lymphoma (17.6% vs 31.3%) compared with non-Hispanic whites. There were no differences with respect to sex, exposure to TBI, or the presence of active chronic GvHD. Hispanics were significantly less likely to report a chronic health condition of any severity (57.2% vs 69.1%; P < .01) and of grade 3 or 4 severity (16.4% vs 19.6%; P = .04) or to report multiple (��2) health conditions (43.4% vs 51.9%; P = .05) compared with non-Hispanic whites (Table 2). Commonly occurring grade 3 or 4 health conditions for the entire study population included gastrointestinal complications (10.7%), musculoskeletal complications (10.1%), audiovisual impairment (8.5%), and second malignant neoplasms (7.6%). The prevalence of the specific types of chronic health conditions reported by Hispanics and non-Hispanic whites did not differ. Multivariate analysis (Table 3) revealed that Hispanics were less likely to report a grade 3 or 4 health GSK3235025 clinical trial condition compared with non-Hispanic whites (OR, 0.47; 95% CI, 0.27-0.83; P = .009) in Model 1, which did not contain education, and health insurance status. The introduction of those sociodemographic variables diminished both the magnitude and the significance of the association between ethnicity and health conditions (OR, 0.56; 95% CI, 0.29-1.08; P = .08). Other variables that were associated with an increased reporting of grade 3 or 4 chronic health conditions included the presence of active chronic GvHD (OR, 3.99; 95% CI, 1.94-8.24; P = .002), health insurance coverage (OR, 3.46; 95% CI, 1.5-8.01; P = .004), and exposure to TBI (OR, 1.94; 95%CI, 1.06-3.56; P = .03). Individuals with active Histamine H2 receptor chronic GvHD were significantly more likely to report grade 3 or 4 audiovisual impairment (25% vs 9.1%; P = .04), endocrinopathies (25% vs 7.7%; P = .03), and gastrointestinal complications (28% vs 9.1%; P = .02) compared with other allogeneic HCT recipients who did not have active chronic GvHD. Participants who received TBI were significantly more likely to report grade 3 or 4 musculoskeletal complications (12.8% vs 3.1%; P = .01) or gastrointestinal complications (10.9% vs 3.1%; P = .03) compared with participants who were not exposed to TBI. The cumulative incidence of chronic health conditions among Hispanics and non-Hispanic whites was 35% (95% CI, 30%-40%) and 43% (95% CI, 41%-46%) at 10 years after HCT, respectively (P < .01) (Fig. 1). Corresponding estimates for grade 3 or 4 chronic health conditions were 8% (95% CI, 5%-11%) and 10% (95% CI, 8%-11%), respectively; and the estimates for grade 5 chronic health conditions were 11% (95% CI, 8%-15%) and 14% (95% CI, 12%-16%), respectively. The overall objective of this study was to determine whether ethnic differences existed in the prevalence of chronic health conditions after HCT.
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