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  • 37?��?1.14, P?=?0.001). The knee adduction angular impulse had a significant relationship with meniscus tear location (medial, lateral, both or none) (P?=?0.023), with a higher peak in the patients with medial tears compared to patients MI-773 with no tears (2.41?��?1.09 vs 1.20?��?1.33, P?=?0.022) and patients with both medial and lateral tears (2.41?��?1.09 vs 1.28?��?1.26, P?=?0.007) [ Fig.?1(B)]. There was no significant effect of the tear location (medial, lateral, both or none) on gait speed (P?=?0.408) ( Fig.?2). The associations between each individual meniscus, bone and cartilage characteristic and the knee adduction moment are presented in Table III. Patients with a higher peak knee adduction moment had a larger medial meniscus extrusion and a lower medial meniscus height. The opposite relationship was observed for the lateral meniscus: patients with a higher peak knee adduction moment had a smaller lateral meniscus extrusion and a higher lateral meniscus height. These relationships became slightly stronger after adjusting for gait speed, age, BMI and OA severity. No statistically significant association was observed between denuded area and cartilage thickness and knee adduction moment (P?>?0.05) and adjusting for gait speed, age, BMI and OA severity did not change the relationships. There was a moderate correlation (r?=?0.31, P?<?0.028) between subchondral tibial bone ratio and knee adduction moment with a higher knee adduction moment related to a larger medial <a href="http://www.selleck.cn/products/AZD6244.html">Selumetinib tibial bone surface. No statistically significant correlation was observed between the subchondral femoral bone ratio and the knee adduction moment. Ribociclib mouse No statistically significant correlation was found between tibial and femoral cartilage thickness ratios and knee adduction moment. Similar results were found in the adjusted model. The associations between each individual meniscus, bone and cartilage characteristic and the knee adduction angular impulse are presented in Table IV. Patients with a higher knee adduction angular impulse had a larger medial meniscus extrusion. The opposite relationship was observed for the lateral meniscus: patients with a higher knee adduction angular impulse had a smaller lateral meniscus extrusion. These relationships did not change after adjusting for gait speed, age, BMI and OA severity. Denuded area and cartilage thickness were not statistically significant associated with knee adduction angular impulse except for lateral femoral thickness. Patients with a larger knee adduction angular impulse had a thicker lateral femoral cartilage and lower medial/lateral femoral cartilage thickness ratio. Adjusting for gait speed, age, BMI and OA severity did not change the relationships. There was a statistically significant association between knee adduction angular impulse and subchondral tibial bone ratio but the significance disappeared after adjusting for gait speed, age, BMI and OA severity.

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