8 Awesome Items About LY2109761
  • Our primary outcome was whether a patient reported taking a goal dose of beta-blocker, statin, and ACEI/ARB at 12 months after AMI. To standardize comparisons of medications within the same class (e.g., metoprolol and carvedilol for beta-blockers), we classified medication doses into categories, relative to the target dose for that medication. The target dose for each medication was defined by the landmark clinical trials that established EPZ5676 order clinical benefit for each medication in AMI (see Online Tables?1 to 3 for target doses for each medication, the clinical trials demonstrating clinical efficacy, and the mean achieved doses in the trials). Beta-blockers, statins, and ACEI/ARBs that were not indicated by U.S. Food and Drug Administration labeling for patients after AMI or with concurrent heart failure (and thus did not have a target dose for these conditions) were considered ��other�� and excluded from the respective analyses. For example, medications such?as labetalol and losartan are only indicated for the treatment of hypertension and thus do not have established target doses for secondary prevention in AMI. Overall, this?exclusion affected 1% of patients taking beta-blockers, 0% of?patients taking statins, and 6% of patients taking ACEI/ARBs. A person was considered to be taking a goal dose of a medication if the dose was at least 75% of the target dose. A dose that was 50% to 74% of target was considered moderate Staurosporine intensity, whereas doses below 50% of target were considered low. Although we excluded patients with SBP?<100 mm Hg from the beta-blocker and ACEI/ARB analyses, because these patients would be difficult to get on?any dose regime of these medications, patients with SBP?<110 <a href="http://www.selleckchem.com/products/ly2109761.html">TGF-beta inhibitor mm Hg might similarly be difficult to up-titrate.?As such, a fifth category of patients was created for the beta-blocker and ACEI/ARB analyses that included these patients, which was labeled ��on medication/unable to titrate.�� The percentages of patients at the various dose categories (goal, moderate, low, none, on medication/unable to titrate) of beta-blockers, statins, and ACEI/ARBs were examined at the time of hospital discharge and at 12-month follow-up. We also examined rates of up-titration during the first year of follow-up, which was defined as an increase in the dose category of a medication from discharge to follow-up (e.g., increasing from a low dose?to a moderate or goal dose). Although 12-month follow-up was examined, some patients (20% of cohort) only had 6-month follow-up data, in which case the medications reported at 6 months were used for the follow-up analyses.

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