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  • 0001), and lower LV longitudinal strain. By contrast, there was no significant difference between groups for LV end-systolic volume, mass Navitoclax cell line and ejection fraction, mitral E wave, E/A, and E/Ea ratios. Of note, there was no significant difference in event-free survival according to the tertiles of LVEF (tertile 1: 55% to 61%, tertile 2: 62% to 70%, tertile 3: 71% to 85%; p = 0.90). Univariable Cox proportional hazard model (Table 4) showed that AS severity parameters, valvulo-arterial impedance, LV volumes and longitudinal strain, mitral A wave, indexed LA area, and BNP were significantly associated with event-free survival. In addition, compared with patients with NF/LG (referent), those with LF/LG had a worse outcome (hazard ratio [HR]: 4.54, 95% confidence interval [CI]: 1.99 to 11.1, p = 0.001). Patients with LF/HG also tended to have lower cardiac event-free survival than NF/LG group. On multivariable ABT-199 supplier analysis, after adjustment for univariable predictive factors, peak aortic velocity (HR: 1.7, 95% CI: 1.04 to 2.84, p = 0.035), LV end-diastolic volume (HR: 1.01, 95% CI: 1.01 to 1.02, p = 0.002), and indexed LA area (HR: 1.13, 95% CI: 1.06 to 1.2, p < 0.0001) were independently associated with event-free survival. Moreover, in the same multivariable model, the new proposed AS grading classification according to flow and gradient was also an independent predictor of event-free survival (p = 0.009) (Fig. 2). The LF/LG (HR: 5.26, 95% CI: 2.04 to 14.3, p = 0.045) Tofacitinib and LF/HG (HR: 2.38, 95% CI: 1.02 to 5.55, p = 0.001) were identified as strong independent determinants of poor prognosis as compared with NF/LG (Table 4). Interestingly, when adding the risk score in the model, the new proposed AS grading classification remained independently associated with outcome (p = 0.03). In this model, the risk score was significantly associated with the occurrence of cardiac event (HR: 1.21, 95% CI: 1.05 to 1.4, p = 0.009). In multivariable analysis, ��LF�� alone was independently associated with reduced cardiac event-free survival (HR: 1.8, 95% CI: 1.08 to 3.1, p = 0.024). In the same model, excluding ��LF�� variable, ��LG�� was also an independent predictor of reduced cardiac event-free survival (HR: 2.4, 95% CI: 1.4 to 4.2, p = 0.003). Finally, when we added the 2 variables in the model, both ��LF�� and ��LG�� emerged as independent predictors (HR: 1.7, 95% CI: 1.01 to 2.9, p = 0.046; HR: 2.3, 95% CI: 1.3 to 4.0, p = 0.004, respectively). We also found similar results when the variables were included in a continuous format (i.e., indexed LV stroke volume and mean pressure gradient). Furthermore, in a multivariable model, limited to patients with LF, LF/LG was an independent predictor of low cardiac event-free survival when compared with LF/HG (HR: 5.4, 95% CI: 1.03 to 28.6, p = 0.046). Similarly, when compared with the NF/HG group (i.e.

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