Some Of The Most Left Out Answer For Cobimetinib
  • Studies were excluded if one of the following existed: (1) review articles and editorials; (2) case reports; (3) repeat or overlapping publications; (4) no report about the genotype frequency, Bumetanide or insufficient information for data extraction. Two investigators (ZJM and HZR) collected the data independently from all eligible publications. Disagreements about eligibility were resolved during a consensus with a third reviewer (RC) until consensus was achieved on every item. The following data were extracted from each study: name of the first author, year of publication, country of the study, ethnicity, number of cases and controls, genotype and allele frequencies, and genotyping method. Populations were categorized into Asian and non-Asian. The strength of relationship between eNOS-4b/a polymorphism and DN risk was expressed with OR and corresponding 95% CIs. The association was evaluated with the use of the allelic model (a vs b), as well as the additive model (aa vs. bb), the dominant model (aa?+?ab vs bb) and the recessive model (aa vs ab?+?bb). Heterogeneity was assessed using the Cochran Q chi-square test and the I2 test (DerSimonian and Laird, 1986). A P value less than 0.10 indicated significant heterogeneity. We considered I2 values less than 25% to represent low heterogeneity, values between 25% and 50% to represent moderate heterogeneity, and values of 50% or greater to represent high heterogeneity. selleck The fixed-effects model (FEM) was used when there was no heterogeneity among the included studies; otherwise, the random-effects model (REM) was used. In the subgroup analysis, statistical analysis was conducted according to different geographic location. Sensitivity analysis was performed to estimate the stability by omitting one study at a time to examine influence of one study on the overall summary estimate. Funnel plot and Egger's test were performed to assess publication bias (Begg and Mazumdar, 1994?and?Egger et al., 1997). An asymmetric plot or the P-value of Egger's test less than 0.1 suggested possible publication bias. Analyses were performed using the software Review Manage 5.2, publication bias was conducted using STATA software (version 12.0; Stata, College Station, TX). A two-sided P?<?0.05 was considered statistically significant. A total of 59 articles were identified. The flow chart of study selection is shown in Fig.?1. Of these, 41 were excluded because they did not meet the criteria or were over-lapping publications. Finally, a total of 18 studies published between 2000 and 2013 were identified according to our inclusion criteria, involving 2972 cases and 2700 controls.</div>

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