Eight persons were removed from the analyses because they did not have surgery (n = 4) or had more than 2 surgical treatments (n = 4). From the 217 participating women, 77 (35.5%) needed 1 repeat surgical treatment. Eight persons (10.4%) received a second operation due to complications. Twenty-two women (28.6%) were converted from BCT to MTC in a second surgery. No differences were found between the women who received 1 or 2 surgical selleck kinase inhibitor
treatments with regard to sociodemographic variables. However, women differed on the clinical characteristics: hormone therapy (yes/no), type of surgery (BCT/MTC) and disease stage (stage 0/I/IIa/IIb) (see Table 1). Concerning fatigue, women with 1 or 2 surgical treatments did not score differently on symptoms of fatigue [F(1,105) = 0.01, p = 0.92]. However, an effect for time was found (See Table 2). Mean scores of fatigue scores at Time-1 (20.03 �� 7.36) were statistically lower than scores at Time-2 (22.95 �� 7.52, p < 0.0001) and Time-3 (22.94 �� 8.09, p < 0.0001). In addition, mean fatigue scores at Time-5 (20.57 �� 7.11) were significantly lower than mean scores at Time-2 (p = 0.001) and Time-3 (p < 0.0001). No relationship was found between time and number of surgical treatments. After controlling for clinical factors, the effect for time did not remain significant [Wilks' Lambda = 0.97, F(4,99) = 0.89, p = 0.474, partial eta squared = 0.04]. Women with 1 or 2 surgical treatments did not differ on symptoms of anxiety [F(1,92) = 0.013, p = 0.91). However, an effect for time was found, indicating DAPT
a decrease in symptoms of anxiety over time (see Fig. 2). Mean scores of state anxiety scores at Time-1 were statistically different from scores at subsequent time points (p < 0.0001). In addition, scores on Time-2 (37.00 �� 11.26) were different from scores on Time-5 (34.38 �� 10.63, p = 0.047). No relationship was found between time and number of surgical treatment. After controlling for possible confounders, the effect for time remained significant [Wilks' Lambda = 0.72, F(4,86) = 8.55, p < 0.0001, partial eta Bleomycin ic50
squared = 0.29]. Women with 1 and women with 2 surgical treatments did not differ on symptoms of depressive symptoms [F(1,109) = 0.14, p = 0.71, partial eta squared = 0.001, observed power = 0.07). Concerning depressive symptoms, an effect for time was found, indicating that depressive symptoms decrease over time. Mean scores of depressive symptoms at Time-1 (14.54 �� 9.61) were statistically different from Time-4 (11.68 �� 10.25, p= 0.02) and Time-5 (10.31 �� 8.50, p < 0.0001). Mean scores at Time-5 were also different from Time-2 (13.08 �� 9.78, p = 0.001) and Time-3 (12.63 �� 9.95, p = 0.003). No interaction effect was found. After controlling for possible confounders, the effect for time did not remain significant [Wilks' Lambda =.93, F(4,103) = 1.94, p = 0.11, partial eta squared = 0.07].