Howdy, Stranger!

It looks like you're new here. If you want to get involved, click one of these buttons!

Mayhem Of the MK-1775

Approving final version of manuscript: AJB, JBP, GJK, SB, KE, JMP, AV, DL, ESh, CEB, MBZ, HM, ESz, SKB, MLB, RC, SK, and SM. AJB takes responsibility for the integrity of the data analysis. ""Chronic kidney disease (CKD) is associated with increased fracture risk and skeletal deformities. The impact of CKD on volumetric bone mineral density (vBMD) and cortical dimensions during growth is unknown. Tibia quantitative computed tomographic scans were obtained in 156 children with CKD [69 stages 2 to 3, 51 stages 4 to 5, and 36 stage 5D (dialysis)] and 831 healthy participants aged 5 to 21 years. Sex-, race-, and age- or tibia length�Cspecific Z-scores were generated for trabecular BMD (TrabBMD), MK-1775 cortical BMD (CortBMD), cortical area (CortArea) and endosteal circumference (EndoC). Greater CKD severity was associated with a higher TrabBMD Z-score in younger participants (p?<?.001) compared with healthy children; this association was attenuated in older participants (interaction p?<?.001). Mean CortArea Z-score was lower (p?<?.01) in CKD 4�C5 [?0.49, 95% confidence interval (CI) ?0.80, ?0.18)] and CKD 5D (?0.49, 95% CI ?0.83, ?0.15) compared with healthy children. Among CKD participants, parathyroid hormone (PTH) levels were positively associated with TrabBMD Z-score (p?<?.01), and this association was significantly attenuated in older participants (interaction p?<?.05). Higher levels of PTH and biomarkers of bone formation (bone-specific alkaline <a href="">PD-1/PD-L1 phosphorylation phosphatase) and resorption (serum C-terminal telopeptide of type 1 collagen) were associated with lower CortBMD and CortArea Z-scores and greater EndoC Z-score (r?=?0.18�C0.36, all p?��?.02). CortBMD Z-score was significantly lower in CKD participants with PTH levels above versus below the upper limit of the Kidney Disease Outcome Quality Initiative (KDOQI) CKD stage-specific DNA Damage inhibitor target range: ?0.46?��?1.29 versus 0.12?��?1.14 (p?<?.01). In summary, childhood CKD and secondary hyperparathyroidism were associated with significant reductions in cortical area and CortBMD and greater TrabBMD in younger children. Future studies are needed to establish the fracture implications of these alterations and to determine if cortical and trabecular abnormalities are reversible. ? 2011 American Society for Bone and Mineral Research During childhood and adolescence, skeletal development is characterized by sex- and maturation-specific increases in trabecular and cortical bone mineral density (BMD) and cortical dimensions.1, 2 Children with chronic kidney disease (CKD) have numerous risk factors for impaired bone acquisition, including growth failure, delayed puberty, metabolic acidosis, vitamin D deficiency, muscle deficits, and secondary hyperparathyroidism. In adults, CKD has been associated with higher and lower trabecular BMD, lower cortical BMD, smaller cortical thickness, and higher risk of fractures.</div>
Sign In or Register to comment.