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Are LBH589 Actually Worth The LBH589?

The ensuing deformation was applied to the individual EPI volumes. To improve signal-to-noise ratio and compensate for residual anatomical variations, images were smoothed by a 5-mm FWHM Gaussian. The time-series data of each voxel were processed as follows (Eickhoff et al., 2011; Weissenbacher et al., 2009; Zu Eulenburg et al., 2012): In order to reduce spurious correlations, variance that could be explained by the following nuisance variables was removed: i) the six motion parameters derived from the image realignment, ii) the first derivative of the realignment parameters, and iii) mean gray matter, white matter and CSF signal per time-point as obtained by averaging across voxels attributed to the respective tissue class in the SPM8 segmentation. All nuisance variables entered the model as first and second order. Data were then band pass filtered preserving frequencies between 0.01 and 0.08?Hz, since meaningful resting-state correlations will predominantly be found in these frequencies given that the bold-response acts as a low-pass filter (Biswal et al., 1995; Fox Pentamorphone and Raichle, 2007). We used the same seed regions as for the MACM analysis, i.e., the clusters of convergent atrophy obtained from the meta-analysis, and performed conjunction analyses of resting-state co-activations between striatal and cortical seeds (MOG-striatal, IFJ-striatal, M1-striatal maps). Linear (Pearson) correlation coefficients between the time series of the seed regions and all other gray matter voxels in the brain were computed to quantify resting-state functional connectivity (Reetz et al., 2012). These voxel-wise correlation coefficients were then transformed into Fisher's Z-scores and tested for consistency across subjects in a random-effects selleck chemicals analysis after accounting for subjects' age as a nuisance regressor. In correspondence with the MACM co-activation analysis described above, we first assessed resting-state connectivity using HD-related (left and right) striatal atrophy as seeds ( Fig. 1A). In order to delineate task-free functional connectivity shared by both striatal and cortical atrophy seeds (i.e., MOG-striatal, IFJ-striatal, M1-striatal maps), we then performed conjunction analyses ( Nichols et al., 2005) between resting-state connectivity of striatal and cortical clusters, using premanifest and manifest atrophy regions respectively ( Fig. 2A). Analogous to MACM, the results were thresholded at a cluster-level FWE corrected p?<?0.05 (cluster-forming threshold at voxel-level p?<?0.001). Finally, resting-state co-activation maps of the different cortico-striatal seeds were contrasted using exclusive masking (uncorrected mask at p?<?0.05) and thresholded at a cluster-level FWE corrected p?<?0.05 (p?<?0.001 at the voxel-level).</div>
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