We performed a 7-week COPD rehabilitation program in 140 COPD patients. All patients who completed the program were randomised for additional six supervised supplemental exercise sessions or follow-up examinations without exercise. Both groups were followed for 12?months. The aim was to investigate whether there was any benefit of a brief supplemental exercise program Sitaxentan
with regard to exercise capacity and disease-specific QoL. The study took place at Glostrup Hospital. Glostrup Hospital is functioning both as a University hospital and as a general district hospital for 165?000 inhabitants from six different municipalities situated in the South-western part of Copenhagen. A letter with information about the COPD program was sent to all local GPs within the municipalities. COPD patients were referred to the rehabilitation program by their GPs as well as by the medical department at Glostrup Hospital. The following inclusion criteria were used: (i)?? Forced expiratory volume in 1?s Alectinib
(FEV1)/Forced Expiratory Ventilatory Capacity (FVC)?<?70% of predicted measured at a time of clinical stability and less than 20% reversibility of FEV1 in response to inhaled ��2-agonist. All patients started a basic 7-week rehabilitation program. The physical part of the rehabilitation program was adopted from guidelines of the Danish Society of Respiratory Medicine (http://www.lungemedicin.dk/
) using the shuttle walking test (15, 16) and has been described previously (17). Spirometry was performed and FEV1 in per cent of predicted was calculated based on height, age and gender (18). The rehabilitation program was supervised by a physiotherapist, a specialised respiratory nurse and a nurse specialised as smoking cessation counselor. The program consisted of two sessions per week for 7?weeks. Each session lasted about 1.5�C2?h. The sessions started with a warm-up exercise followed by individually planned walking and cycle training. In addition the patients were taught about four exercise activities <a href="http://www.selleckchem.com/screening/anti-cancer-compound-library.html
">Anticancer Compound Library price aimed to strengthen legs, arms, abdominal and thoracic muscles. The endurance shuttle walking time (ESWT) was measured as the sub-maximal exercise performance, when the patient walk at a constant speed equating to 85% of predicted VO2 peak as calculated from the incremental shuttle walking test. For each patient the same speed was used at follow-up. Patients were asked to walk as long as possible at this rate. The time the patient could walk at this speed was defined as the ESWT. Once a week patients attended a teaching session including skills promotion, disease mastery and illness control, smoking cessation (if relevant), pulmonary physiology, mechanisms of dyspnoea, the importance of physical exercise, medications for treatment of COPD and how to use it, as well as methods for clearance of bronchial secretions. The patients were encouraged to train and walk every day at home and the walking time was recorded in a diary.