In the OCT program, a difference of 100 of A-scan location was equivalent with 195??m. POAG and NTG patients were compared with respect to age, refraction, IOP, central corneal thickness, MD, RNFL thickness and Depth1 using Mann�CWhitney U-test. Age distribution and sex ratio were compared between the two groups using ��2 test. Partial correlation coefficients C646 solubility dmso
of RNFL, and Depth1 with age adjusted by MD and IOP were acquired. Fisher's Z transformation was used to compare the correlation coefficients between the two groups. Bonferroni correction for multiple comparisons was also applied. Descriptive statistics of demographic and ophthalmic measurements are presented in Table?1. This observational, cross-sectional study included 26 eyes of 26 POAG patients and 52 eyes of 52 NTG patients. The mean age at diagnosis, age distribution, sex ratio, refraction, central corneal thickness and MD were not different between the two groups. The mean IOP was significantly higher in the POAG group than in the NTG group (23.5?��?4.3 vs. 15.4?��?2.7?mmHg, P?<?0.001). Table?2 compares RNFL thickness (?m) and cross-sectional Depth1 (?m) between POAG and NTG patients. Significant differences between the POAG and NTG groups in RNFL thickness were found at 11 o'clock (��?=?0.05). After the Bonferroni correction (��?=?0.0021; 24 comparisons), there were no significant differences between the two groups in each clock-hour RNFL thickness. Table?3 includes partial correlation between OCT parameters (RNFL thickness and Depth1) and age adjusted by IOP and MD value. In the POAG group, partial correlation <a href="http://www.selleckchem.com/products/azd5363.html
coefficients between RNFL thickness at 7 and 8 o'clock and age were significant (��?=?0.05). Moreover, partial correlation coefficients between Depth1 at 12, 1, 2, 3, 4, 5, 6, 8, 9, 10 and 11 o'clock and age were significant (��?=?0.05). After the Bonferroni correction (��?=?0.0021; 24 comparisons), no partial correlations were significant between RNFL thickness and age. Still, partial correlation coefficients between Depth1 at 12, 1, 2, 3, 4, 9, 10 and 11 o'clock and age were significant. In the NTG group, there were no significant partial correlation coefficients between any clock-hour RNFL thickness and age. Also, no significant partial correlation was found between Depth1 and age. Significant differences between the POAG and NTG groups in partial correlation coefficients were found in RNFL thickness at 7, 8, 9 and 10 o'clock, and Depth1 at each clock-hour (��?=?0.05). After the Bonferroni correction (��?=?0.0021), significant differences were found only in Depth1 at 12, 1, 2, 4, 8, 9, 10 and 11 o'clock. For comparison, representative correlations between Depth1 at 12 o'clock and age in the POAG group and NTG group are shown in Figure?3. This study was designed with the major objective of determining whether the correlation of the amount of laminar displacement with age differs between POAG and NTG patients.