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One Ought To See These Particular Remarkable EAI045 Vids

Research is on its way with different strategies to address meal disturbance and to find ways to minimise postprandial hyperglycaemic events. However, the semi-closed-loop model should be seen as an intermediate step in the development process, not the end-product. Even though the hybrid model is currently the most effective controller, insulin infusion without any user intervention is the ultimate goal. Kovatchev B1,2, Cobelli C3, Renard E4, Anderson S5, Breton M1, Patek S2, Clarke W6, Bruttomesso D7, Maran A7, Costa S7, Avogaro A7, Mann CD3, Facchinetti A3, Magni L8, Nicolao GD8, Place J4, Farre A4 1Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA,2Department of Systems and Information PLX-4720 Engineering, University of Virginia, Charlottesville, VA, USA,3Department of Information Engineering, University of Padova, Padova, Italy,4Department of Endocrinology and UMR CNRS, CHU and University of Montpellier, Montpellier, France,5Department of Medicine, Section Endocrinology, University of A-1331852 nmr Virginia, Charlottesville, VA, USA,6Department of Pediatrics, University of Virginia, Charlottesville, VA, USA,7Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy, and8Department of System and Informatics, University of Pavia, Pavia, Italy J Diabetes Sci Technol 2010;4: 1374�C81 Background: Increasing effort has been focused on the development of subcutaneous�Csubcutaneous (SC-SC) closed-loop glucose control, using CGM coupled with an insulin pump and a control algorithm. This paper summarised data found in a previous publication. Methods: The design of the control algorithm was done entirely in silico. Adults (n?=?20) were recruited for the clinical experiments from the USA, Italy and France. All subjects participated in both open-loop and closed-loop sessions, which were scheduled 3�C4?weeks apart lasting 22?h each. A CGM and an insulin pump EAI045 cell line were used. During open-loop control the patient performed insulin dosing under physician supervision, whereas a control algorithm performed insulin dosing during closed-loop control. Results: The in silico design resulted in quick and cost-effective system development, testing and regulatory approvals (which took less than 6?months compared with the years it would have taken with animal trials). Closed-loop control reduced nocturnal hypoglycaemia from 23 to five episodes (p?<?0.01). There was a mean of 1.15 hypoglycaemic episodes per subject overnight on open-loop control, which was reduced to 0.25 episodes per subject on closed-loop control. Closed-loop control also increased the amount of time spent overnight within the target range from 64% to 78% (p?=?0.03). However, the percentage of time within the blood glucose target range of 3.9�C10?mmol/l during postprandial breakfast control decreased from 61% in open-loop control to 52% in closed-loop control.</div>
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