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Unanswered Questions Around Ivacaftor Shared

2?mm. MRI data were processed to measure the total volumes of the intracranial space (IC), parenchyma, ventricles and white matter regions (WML) by a fully automatic segmentation program (Software for Neuro-Image Processing in Experimental Research: SNIPER), which was developed at the Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. Detailed procedures of the MRI post-processing by SNIPER have been described elsewhere.[32] SPECT scanning was carried out by using a two-head rotating GCA 7200DI gamma-camera (Toshiba, Otabara, Japan). Imaging was started 15?45?min after injection of 222?MBq (6?mCi) of N-isopropyl-p-[123I] iodoamphetamine (Nihon Mediphysics, Tokyo, Japan), while the participants rested in a supine position with their eyes closed. The data were acquired in 128?��?128 matrices through an 18�� rotation at an angle interval of 4��. The projection data were prefiltered and reconstructed, and Chang's attenuation and scattering corrections were applied.[33] SPECT data were processed using the three-dimensional stereotactic surface projection (3D-SSP) method (Neurostat Software Library; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA).[34] To assess perfusion deficits, the normalized brain activity of each patient was compared with that of 18 normal participants by using a pixel-by-pixel z-score analysis.[33] Qualitative z-score image analysis was carried out by two specialists without any knowledge buy Ivacaftor of the clinical data. An image was defined as showing an AD pattern if the perfusion was decreased in the bilateral parietal association areas and posterior cingulate cortices, with relative sparing of the sensorimotor cortex, occipital cortex and cerebellum. The 3D-SSP technique, together with SPECT and positron emission tomography, provide a high diagnostic accuracy for AD.[34] Statistical analysis was carried out using MI 773 spss 19.0 for Windows (SPSS, Chicago, IL, USA). Comparisons of variables among the three patients groups were carried out by ��2-test and analysis of covariance (ancova), followed by post-hoc analysis (Bonferroni) to detect statistically significant differences. The association between BPSD and HbA1c was analyzed by Spearman's correlation analysis. Independent risks for BPSD were analyzed by multivariate logistic regression. Differences were considered significant at P?<?0.05. Age and education level were similar among the three groups of patients, whereas male sex was more prevalent in diabetic patients with HbA1c <7% (Table?1). The Barthel Index was lower in diabetic patients with HbA1c ��7.0% than those with HbA1c <7.0%. Impaired dressing ability and urinary incontinence were apparent in diabetic patients with higher HbA1c (data not shown). Depressive mood and vitality, as well as caregivers' burden were not different among the three patient subgroups.</div>
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