0001), intra-operative hysterectomy (P?=?0.02), and bleeding (P?=?0.049). From the total of 501 patients, 347 (69.2%) filled and returned the questionnaires (Table?1). After the LP, there was a statistically significant (P?<?0.001) improvement in most of the symptoms: feeling pressure, discomfort or pain in the lower abdomen and genital area, not emptying the bladder, visible POP, urinary frequency, and urge and stress urinary incontinence. There was no statistical significant impact of the <a href="http://www.selleckchem.com/products/liproxstatin-1.html
">Ferroptosis inhibitor operation on the patients' bowel habits and sexual activity. Nearly, 65% of the patients reported a positive impact of LP in urination. Collectively, 86.4% of the patients reported a successful assessment for LP and 94.8% would prefer LP if there was an option to choose an operation for the treatment of POP again. The wide variety of open and laparoscopic surgical Ketanserin
approaches used to treat POP represented the complexity of managing this medical condition.3,8 Irrespective of the route or repair chosen by the surgeon, a sound surgical judgment, complete understanding of the pelvic anatomy and the mechanisms involved in POP, and expertise in pelvic surgery are required if successful outcomes are to be expected.9 Recently, Cavadas et?al. evaluated the way in which the quality of randomized controlled studies (RCT) for the treatment of POP has evolved.10 The quality of reporting was assessed by applying the 2010 revised Consolidated Standards of Reporting Trials (CONSORT) statement. In all RCT were identified for review. Comparing the two periods 1997�C2006 and 2007�C2010, there was no improvement in the quality of reporting for any of the CONSORT criteria. Thus, RCT in POP are scarce, and the quality of reporting is suboptimal and has not improved in recent years. Therefore, the results of RCT between the different surgical procedures for treating POP are warranted. To the best of our knowledge, the present study constitutes the largest series of such trials, including 501 patients. Our results have shown a repeat of the high success rates of open surgery. From the 347 patients who returned the questionnaires, 86.4% reported a successful assessment of the procedure, while the recurrence rate was 11.5%. Ganatra et?al. reviewed 11 laparoscopic PKC inhibitor
studies that included 1197 patients and reported a 10% recurrence rate for POP, which is similar to the present rate.11 However, different definitions of POP recurrence have been used in these studies. The posterior mesh is of great importance for the support of intra-abdominal pressures and thus to avoid recurrences. POP recurrence could be attributed to inadequate healing inherent in the laparoscopic approach. In the same review by Ganatra et?al. the mean incidence of vaginal erosion after LP was 2.7%; similar to the rate in the present study of 2.4%.